Search results for "Lobules of liver"
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Separation and Biochemical Characterization of Rat Liver Parenchymal Cell Subpopulations
1988
Parenchymal cells within the hepatic lobules of the rat are morphologically and biochemically heterogeneous (Shank et al., 1959; Novikoff, 1959; Loud, 1968; Jungermann and Katz, 1982). It has been previously shown that the concentration of cytochrome P-450 and the activities of most cytochrome P-450-dependent monooxygenases are relatively higher in the centrilobular regions than in the periportal regions of the rat liver (Baron et al., 1978; Gooding et al., 1978; Baron and Kawabata, 1983); further, these studies revealed that pretreatment of the animals with phenobarbital intensified this gradation across the liver lobule, whereas after administration of 3-methylcholanthrene the concentrati…
Studies on vinblastine-induced autophagocytosis in mouse liver. III. A quantitative study.
1982
The microtubule inhibitor vinblastine (25 mg/kg, i.p.) induces autophagocytosis in mouse hepatocytes. The formation of autophagic vacuoles, their contents, and other cellular changes after vinblastine injection in hepatocytes, were studied by light and electron microscopic morphometric analysis. The volume density of autophagic vacuoles increased significantly during the experimental period (24 h). This increase was due to the significant increase in their number, which was approximately 5-fold 4 h, 12 h and 24 h after vinblastine injection. The mean volume of the autophagic vacuoles increased significantly 1 h after vinblastine injection, at which time the formation of new autophagic vacuo…